Shape the proposal
Grant development, specific aims and a coherent rationale that connects the knowledge gap to the proposed work.
INDEPENDENT SCIENTIFIC CONSULTANCY TORONTO / INTERNATIONAL
Clarity for
complex science.
Scientific strategy, molecular imaging and biomarker expertise for neuroscience research and early-stage biotech.
01 / WHAT WE DO
Better questions.
More meaningful evidence.
Focused scientific support at the intersection of measurement, interpretation and decision-making.
01
Molecular Imaging
Design and interpret imaging studies with a clear view of what the signal can—and cannot—tell you.
From signal to insight 02Biomarker Strategy
Connect biological questions to measures that are relevant, interpretable and fit for purpose.
From measure to meaning 03Science & Funding
Build a coherent scientific case, from the first research question to a compelling proposal or report.
From idea to a clear caseMOLECULAR IMAGING
A signal is only as useful
as its interpretation.
Quantitative thinking, from study design to the conclusions you draw.
PET can bring a biological question into focus. Making that evidence useful requires careful choices about acquisition, quantification and interpretation—and an honest account of the assumptions behind them.
Discuss an imaging questionAREAS OF SUPPORT
- PET study strategy & imaging endpoint selection
- Quantitative imaging & kinetic modelling applications
- Reference-tissue approaches & their assumptions
- PET/MRI integration
- Partial-volume considerations
- Independent methodological review
The question comes first. The method follows.
BIOMARKER STRATEGY
What does your biomarker
actually measure?
A promising association is the start of a question.
Clarify the biological construct, the sources of variability and the limits of interpretation. Build a multimodal strategy that connects the measure to the decision it needs to inform.
Explore your biomarker strategyONE QUESTION. MULTIPLE PERSPECTIVES.
01
Imaging
Molecular and spatial context
02
Fluid
Biological processes and change
03
Digital
Function and behaviour over time
04
Clinical
Relevance to the people being studied
Complementary evidence. Explicit assumptions.
SCIENTIFIC STRATEGY & GRANTS
Strong science.
A clearer case.
Bring the research question, methods and narrative into alignment. Support for developing ideas, stress-testing the logic and communicating the evidence with precision.
Strengthen the plan
Methods and analysis strategy, with attention to feasibility, assumptions and the conclusions the design can support.
Communicate the evidence
Reviewer responses, manuscripts and scientific reports that make the reasoning clear and the limitations explicit.
WHO WE WORK WITH
Early-stage biotech
Scientific perspective for emerging CNS programmes and evidence plans.
Research groups
Focused collaboration on study design, quantitative methods and funding.
Imaging & biomarker companies
Independent input on measurement, interpretation and scientific communication.
ABOUT caemālia
Careful measurement.
Thoughtful scientific judgement.
caemālia is a specialist scientific consultancy focused on molecular imaging, CNS biomarkers and scientific strategy.
The work connects biological questions with measurement, methodology and interpretation—helping neuroscience research teams and early-stage biotech examine their assumptions and define the evidence they need.
Each engagement begins with a focused question and an agreed scope, with clear deliverables and practical recommendations.
Areas of focus include quantitative PET, SV2A and synaptic-density imaging, tau and neurodegeneration, PET/MRI methodology, scientific writing and grant development.
02 / HOW WE WORK
A clear process.
A useful outcome.
A focused review or a longer collaboration. The scope is built around your question.
Define
Clarify the question, the decision it informs and the evidence already available. Agree on scope and deliverables.
Design
Examine the options and assumptions. Develop a fit-for-purpose scientific or analytical approach.
Deliver
Translate the work into clear recommendations, practical next steps and materials your team can use.
A FOCUSED PLACE TO START
Independent
Scientific Review
A second scientific perspective on a study protocol, imaging analysis plan, biomarker strategy or grant proposal—before the next important decision.
Discuss a reviewWHAT YOU RECEIVE
- 01 A focused review of agreed materials
- 02 A written assessment of strengths, gaps and assumptions
- 03 Prioritized recommendations and next steps
- 04 A discussion to work through the findings
Scope, timing and fees agreed before work begins.
SCIENTIFIC PERSPECTIVES
See how we
examine the evidence.
One-page scientific perspectives with published sources, explanatory frameworks and clearly labelled illustrative examples.
01
Independent scientific review
Read PDF 1 page02When a PET signal changes, what can we conclude?
A fictional amyloid-PET study, examined from measured change to biological interpretation.
Molecular imaging
Read PDF 1 page03Tau PET: from binding to clinical meaning.
Tau families, tracer-specific off-target binding and the distinction between association and monitoring.
Biomarker strategy
Read PDF 1 page04What does your biomarker actually measure?
Using fictional [18F]CAE and SENY to separate the biological question from the measured quantity.
Science and funding
Read PDF 1 page05A stronger grant starts with a sharper question.
A fictional aim refined into a coherent question, study design and achievable inference.
Multimodal scientific review
Read PDF 1 page06When biomarkers disagree, what should you believe?
An evidence network for a fictional PET, fluid and cognition result that does not tell one simple story.
Biomarker validation
Read PDF 1 pageFrom measurement to clinical benefit.
Analytical validation, clinical validation and clinical utility: three questions, three types of evidence.
LET’S START WITH THE QUESTION
Working on a complex
scientific question?
Let’s determine what evidence you need.
Share a little about your project,
the decision ahead and your timeline.
Email a short introduction or attach your project brief.
Please keep initial enquiries non-confidential. Privacy & sharing information